sherpa/romeo

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dc.contributor.authorSüzen, Sibel
dc.contributor.otherGürkök, Gökce
dc.contributor.otherÇoban, Tülay
dc.date.accessioned2020-03-17T12:44:06Z
dc.date.available2020-03-17T12:44:06Z
dc.date.issued2006
dc.identifier.urihttps://doi.org/10.1080/14756360500533109tr_TR
dc.identifier.urihttp://hdl.handle.net/20.500.12575/70697
dc.description.abstractOxidative stress has been implicated in the development of many neurodegenerative diseases such as Parkinson and Alzhemier's disease and is also responsible for aging, artherosclerosis, rheumatoid arthritis and carcinogenesis. Olefins such as dehydroalanines have been shown to inactivate free radicals by forming stabilized free radical adducts. Among these molecules N-acyl dehydroalanines react with and scavenge oxygen and hydroxyl radicals. This study describes the synthesis, characterization and in vitro effects on rat liver lipid peroxidation levels, and DPPH free radical scavenging activities of some N-acyl dehydroalanine derivatives. Compounds c, f and j slightly scavenged the level of DPPH radical at 10-3 M concentration by about 27, 46, and 56%, respectively while compounds a, d, e, f, g, h showed a strong inhibitory effect on lipid peroxidation at 10-3 M and 10-4 M concentrations and inhibition was in the range of 76-90%. The possible antioxidant mechanism of the compounds was discussed. © 2006 Taylor & Francis.tr_TR
dc.language.isoentr_TR
dc.relation.isversionof10.1080/14756360500533109tr_TR
dc.subjectDehydroalaninetr_TR
dc.subjectFree radicaltr_TR
dc.subjectLipid peroxidationtr_TR
dc.subjectRadical scavengingtr_TR
dc.subjectSynthesistr_TR
dc.titleNovel N-acyl dehydroalanine derivatives as antioxidants: Studies on rat liver lipid peroxidation levels and DPPH free radical scavenging activitytr_TR
dc.typeArticletr_TR
dc.relation.journalJournal of Enzyme Inhibition and Medicinal Chemistrytr_TR
dc.contributor.departmentEczacılık Fakültesitr_TR
dc.identifier.volume21tr_TR
dc.identifier.issue2tr_TR
dc.identifier.startpage179tr_TR
dc.identifier.endpage185tr_TR
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıtr_TR
dc.identifier.issn/e-issn1475-6366
dc.identifier.issn/e-issn1475-6374
dc.description.indexwos
dc.description.indexScopus


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