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dc.contributor.authorSüzen, Sibel
dc.contributor.otherShirinzadeh,Hanif
dc.contributor.otherInce,Elif
dc.contributor.otherWestwell, Andrew D.
dc.contributor.otherGurer, Hande
dc.date.accessioned2020-03-17T12:11:17Z
dc.date.available2020-03-17T12:11:17Z
dc.date.issued2015
dc.identifier.urihttps://doi.org/10.3109/14756366.2015.1132209tr_TR
dc.identifier.urihttp://hdl.handle.net/20.500.12575/70689
dc.description.abstractMelatonin (MLT) is a well-known free-radical scavenger, involving in the prevention of cellular damage that can lead to cancer, ageing and a variety of neurodegenerative diseases. Research on MLT-related compounds has been required to optimise the maximum pharmaceutical activity with the lowest side effects. In our ongoing research, we have synthesized new indolebased MLT analogues as potential antioxidant agents by modifying the MLT molecule. In this study, we build on previous findings, through the synthesis, characterization and in vitro antioxidant profiling of a series of new indole-based MLT analogues which possess triazole, thiadiazole and carbothioamides on the third position on the indole ring. In vitro antioxidant activity was investigated by evaluating their reducing effect against oxidation of a redox sensitive fluorescent probe and their radical scavenging activity was assessed via the DPPH assay. In addition, in vitro cytotoxic effects of newly synthesized compounds were investigated in CHO-K1 cells using the MTT assay.tr_TR
dc.language.isoentr_TR
dc.relation.isversionof10.3109/14756366.2015.1132209tr_TR
dc.subjectAntioxidant,tr_TR
dc.subjectantioxidant activity,tr_TR
dc.subjectcytotoxicity,tr_TR
dc.subjectindole,tr_TR
dc.subjectmelatonintr_TR
dc.titleNovel indole-based melatonin analogues substituted with triazole, thiadiazole and carbothioamides: studies on their antioxidant, chemopreventive and cytotoxic activitiestr_TR
dc.typeArticletr_TR
dc.relation.journalJournal of Enzyme Inhibition and Medicinal Chemistrytr_TR
dc.contributor.departmentEczacılık Fakültesitr_TR
dc.identifier.volume31tr_TR
dc.identifier.issue06tr_TR
dc.identifier.startpage1315tr_TR
dc.identifier.endpage1321tr_TR
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıtr_TR
dc.identifier.issn/e-issn1312-1321


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