New Antioksidant Durg Development Studies on Neurohormone Melotonin and Synthetic Analogues

Abstract

Antioxidants scavenge and prevent the formation of free radicals so they are exceedingly important for the treatment and management of these kinds of diseases. Therefore, in recent years, there has been an increasing interest in finding new antioxidant compounds. Oxidant molecules can cause extensive damage to DNA, protein, and lipids. This is a major reason of aging and many degenerative diseases of aging such as cancer, cardiovascular disease, immune-system decline and brain dysfunction. Melatonin (0/7) synthesized mainly in the pineal gland, has a number of physiological functions. Main functions include regulating circadian rhythms, reimbursement of free radicals, help to improve immunity and generally inhibiting the oxidation of biomolecules directly or indirectly. With this study based on MLT, series of new indole imines were developed. Three parts of the MLT molecule were modified in order to find out better antioxidant behavior and structure activity relationship of the new indole analogue compounds. In this ongoing study, the synthesized new MLT analogues are indole hydrazide/hydrazones derivatives that have 5-bromo, 5-chloro and N-methyl substitutions. These studies showed that most of the compounds showed significant antioxidant activity at concentrations comparable with or much higher than that of MLT in the antioxidant experiments of ROS-induced DCFH-DA oxidation, lipid peroxidation and DPPH assay.