Honey prevents hepatic damage induced by obstruction of the common bile duct

Abstract

Aim: To examine the possible effects of honey supplementation on hepatic damage due to obstruction of the common bile duct in an experimental rat model. Methods: The study was performed with 30 malen rats divided into three groups: a sham group, an obstructive jaundice group, and an obstructive jaundice plus honey group. At the end of the study period, the animals were sacrificed, and levels of nitric oxide (NO), an d NO synthase (NOS) activities were measured in liver tissues, and levels of adenosine deaminase (ADA) and alanine transaminase (ALT) activities were measured in serum. Results: B lood ALT and ADA activities were significantly elevated in the jaundice group as compared to those of the sham group. In the obstructive jaundice plus honey group, blood ALT and ADA activities were significantly decreased as compared to those of the jaundice group. In erythrocytes and liver tissues, NO levels were found to be significantly higher in the obstructive jaundice plus honey group compared to those of the sham group. Additionally, NO levels were found to be significantly higher in liver tissues from the animals in the obstructive jaundice plus honey group than those of the jaundice group. Conclusion: Honey was found to be beneficial in the prevention of hepatic damage due to obstruction of the common bile duct. © 2008 The WJG Press. All rights reserved.