Immunohistochemical and histopathological studies of fixed rabies virus in goats
BERKİN, Şenay (Ortak Yazar)
VURAL, S. Atalay (Ortak Yazar)
ALÇIĞIR, G. (Ortak Yazar)
Dil ve Tarih-Coğrafya Fakültesi
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The purpose of this study was to systematically demostrate and compare the development of pathological and immunohistochemical changes in goats which were infected by a fixed rabies virus that was used in vaccines&#8217; production. The results are as follows: In histopathological examinations, varying degrees of inflammatory, degenerative, and necrotic changes were detected in the central nervous system; in the immunoperoxidase (IP) method, intra-and/or extracellular viral antigens were observed on the cerebellum, cornu ammonis, thalamus, pons cerebri, nucleus caudatus, spinal cord, medulla oblongata, Gasserian ganglion, eye and the retropharyngeal lymph nodes; in the immunofluorescence (IF) method, intra-and/or extracellular viral antigens were also seen in the same locations with the exception of retropharyngeal lymph nodes. It was also observed that the antigens were qualitatively and quantitatively well stained with both of methods. However the visibility of antigens in the retropharyngeal lymph nodes besides the central nervous system, and eye and the facilities of applying made the IP method much more advantageous than the IF method.