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Preliminary evaluation of rat kidney aldose reductase inhibitory activity of 2-phenylindole derivatives: Affiliation to antioxidant activity

Süzen, Sibel (2007)

Diabetic complications including nephropathy, neuropathy, and cataract are leading causes of end-stage renal diseases and neurological disorders. Aldose reductase (AR), the rate-limiting enzyme of the polyol pathway, ...

Relatıonshıp between aldose reductase and superoxıde dısmutase ınhıbıtıon capacıtıes of ındole-based analogs of melatonın derıvatıves

Süzen, Sibel (2009)

Aldose reductase (AR) has been implicated in the etiology of diabetic complications. Under diabetic conditions, the elevated vascular glucose level causes an increased flux through the polyol pathway, which induces functional ...