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Rat lung aldose reductase inhibition capacity of substituted indole hydrazide/hydrazone derivatives
Diabetes Mellitus is one of the most serious health problem facing both developed and developing countries. Long term complications lead to morbidity and mortality in patients with diabetes. Increased polyol pathway has ...
Evaluation of rat kidney aldose reductase inhibitory activity of some N-acetyl dehydroalanine derivatives
Aldose reductase (AR) is an enzyme that catalyzes the conversion of glucose to sorbitol, which is in turn converted to fructose by sorbitol dehydrogenase. Increased AR activity has been implicated in the pathogenesis of ...