Now showing items 21-30 of 46
Pharmacological Applications of Nrf2 Inhibitors as Potential Antineoplastic Drugs
Oxidative stress (OS) is associated with many diseases ranging from cancer to neurodegenerative disorders. Nuclear factor-erythroid 2 p45-related factor 2 (Nrf2) is one of the most eﬀective cytoprotective controller against ...
Determination and investigation of electrochemical behaviour of 2-phenylindole derivatives: discussion on possible mechanistic pathways
Some 2-phenyl indole (2PI) derivatives were investigated electroanalytically by voltammetric determination. The electrochemical behaviour of the 2PI derivatives were studied as a function of pH at a glassy carbon and hanging ...
Antibacterial Evaluation of Novel Substituted Cycloheptaindoles in Staphylococcus and Enterococcus Strains
Due to emerging resistances against antibiotics there is a strong need to find novel antibacterial agents with a novel structure to prevent early resistance developments.
Novel N-acyl dehydroalanine derivatives as antioxidants: Studies on rat liver lipid peroxidation levels and DPPH free radical scavenging activity
Oxidative stress has been implicated in the development of many neurodegenerative diseases such as Parkinson and Alzhemier's disease and is also responsible for aging, artherosclerosis, rheumatoid arthritis and carcinogenesis. ...
Antioxidant Properties of Melatonin and its Potential Action in Diseases
In recent years, relationship between free radicals and oxidative stress with aging, cancer, atherosclerosis, neurodegenerative disorders, diabetes, and inflammatory diseases became increasingly clear. Confirming the role ...
Detection of Reactive Oxygen and Nitrogen Species by Electron Paramagnetic Resonance (EPR) Technique
During the last decade there has been growing interest in physical-chemical oxidation processes and the behavior of free radicals in living systems. Radicals are known as intermediate species in a variety of biochemical ...
Rat lung aldose reductase inhibition capacity of substituted indole hydrazide/hydrazone derivatives
Diabetes Mellitus is one of the most serious health problem facing both developed and developing countries. Long term complications lead to morbidity and mortality in patients with diabetes. Increased polyol pathway has ...
Evaluation of rat kidney aldose reductase inhibitory activity of some N-acetyl dehydroalanine derivatives
Aldose reductase (AR) is an enzyme that catalyzes the conversion of glucose to sorbitol, which is in turn converted to fructose by sorbitol dehydrogenase. Increased AR activity has been implicated in the pathogenesis of ...
Synthesis and antioxidant activity evaluations of melatonin-based analogue indole-hydrazide/hydrazone derivatives
Melatonin (MLT) is a hormone synthesized from the pineal gland. It is a direct scavenger of free radicals, which is related to its capability to defend cells from oxidative stress. Recently MLT-related compounds are under ...