Browsing Makale by Department "Eczacılık Fakültesi"
Now showing items 1-20 of 71
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1-n-Butyl-2-(4′-fluorophenyl)-1H-benzimidazole-6-carbonitrile
(2004)The structure of the title compound, C18H16FN3, consists of neutral molecules. The asymmetric unit contains two independent molecules with similar conformations: the dihedral angles between the benzimidazole moiety and ... -
2,6-Dimethyl-4H-1-benzopyran-4-one
(2004)The title compound, C11H10O2, belongs to the class of 4-benzopyrones (also known as chromen-4-ones) with potentially diverse pharmacological activities. It was synthesized by acylation of 2-hydroxy-4-methylacetophenone ... -
3-(4-Chlorobenzyl)-5-(4-oxo-4H-chromen-3-ylmethylene)-1,3-thiazolidine-2,4-dione
(2005)In the title molecule, C20H12ClNO4S, the benzopyran ring system and the thiazolidine ring are planar. The dihedral angle between the chlorobenzyl and thiazolidine rings is 74.42 (8)°. The crystal structure is stabilized ... -
4-Thiazolidinone Derivatives as MMP Inhibitors in Tissue Damage: Synthesis, Biological Evaluation and Docking Studies
(2018)Nine 2-(1,2-benzothiazol-3-yl)-N-(4-oxo-2-phenyl-1,3-thiazolidin-3-yl)propanamides combining a benzisothiazole and 4-thiazolidinone in one framework were designed and synthesized. The aim of the study was to verify their ... -
4-Thiazolidinone derivatives as mmp ınhibitors in tissue damage: synthesis, biological evaluation and docking studies
(2018)Nine 2-(1,2-benzothiazol-3-yl)-N-(4-oxo-2-phenyl-1,3-thiazolidin-3-yl)propanamides combining a benzisothiazole and 4-thiazolidinone in one framework were designed and synthesized. The aim of the study was to verify their ... -
A comparative study: Evaluation of antioxidant activity of melatonin and some indole derivatives
(2005)To understand antioxidant activity and the role played by melatonin, we have designed and tested several new compounds. We present the results in terms of structure-activity relationships, focusing on the lack of the methoxy ... -
A pyridoindole antioxidant SMe1EC2 regulates contractility, relaxation ability, cation channel activity, and protein-carbonyl modifications in the aorta of young and old rats with or without diabetes mellitus
(2018)We studied the effects of treatment with SMe1EC, a hexahydropyridoindole antioxidant, on vascular reactivity, endothelial function, and oxidonitrosative stress level of thoracic aorta in young and old rats with or without ... -
Anti-cancer activity studies of indolalthiohydantoin (PIT) on certain cancer cell lines
(2000)5-(2-Phenyl-3′-indolal)-2-thiohydantoin (PIT) has been evaluated as an anti-cancer compound on several cancer lines organised in to subpanels representing leukemia, melanoma, and cancer of lung, colon, kidney, ovary, breast, ... -
Antibacterial Evaluation of Novel Substituted Cycloheptaindoles in Staphylococcus and Enterococcus Strains
(2019)Due to emerging resistances against antibiotics there is a strong need to find novel antibacterial agents with a novel structure to prevent early resistance developments. -
Antimicrobial Activities of New Indole Derivatives Containing 1,2,4-Triazole, 1,3,4-Thiadiazole and Carbothioamide
(2018)Objectives: In new antimicrobial drug development studies, indole and its derivatives create an important class of compounds. In addition, azoles and their derivatives were recognized to be associated with a variety of ... -
Antimicrobial evaluation of indole-containing hydrazone derivatives
(2011)There has been an increasing importance of drug-resistant pathogens in clinical microbiological and antibacterial research. Indoles and hydrazone-type compounds constitute important classes of compounds in the search for ... -
Antioxidant Properties of Melatonin and its Potential Action in Diseases
(2015)In recent years, relationship between free radicals and oxidative stress with aging, cancer, atherosclerosis, neurodegenerative disorders, diabetes, and inflammatory diseases became increasingly clear. Confirming the role ... -
Behaviour of 9-Ethyl-9H-carbazole Hydrazone Derivatives Against Oxidant Systems: Protective Effect on Amyloid β-Induced Damage
(2019)Antioxidants are helpful in prevention of several diseases related with oxidative stress including neurodegenerative disorders. In recent studies, carbazoles were given proof of promising antioxidant activities. In this ... -
Comparative effect of N-substituted dehydroamino acids and α-tocopherol on rat liver lipid peroxidation activitie
(Journal of Enzyme Inhibition and Medicinal Chemistry, 2009)Free radical damage has been associated with a growing number of diseases and conditions, such as autoimmune diseases, neurodegenerative disorders and multiple types of cancer. Some dehydroamino acids and corresponding ...
