Bölüm "Eczacılık Fakültesi" Makale için listeleme
Toplam kayıt 71, listelenen: 41-60
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Melatonin analogue new indole hydrazide/hydrazone derivatives with antioxidant behavior: Synthesis and structureactivity relationships
(2009)Melatonin (MLT) is a hormone produced in the brain by the pineal gland, from the amino acid tryptophan. It is also an antioxidant hormone with a particular role in the protection of nuclear and mitochondrial DNA. In recent ... -
Methyl 1-n-butyl-2-(3,4-dichlorophenyl)-1H-benzimidazole-5-carboxylate
(2004)A new benzimidazole compound, methyl 1-n-butyl-2-(3,4-dichlorophenyl)-1H-benzimidazole-5-carboxylate, C19H18Cl2N2O2, has been synthesized by the condensation of methyl 3-amino-4-(n-butylamino)benzoate with an Na2S2O5 ... -
Multivariate Optimization and Validation of a Capillary Electrophoresis Method for the Simultaneous Determination of Dextromethorphan Hydrobromur, Phenylephrine Hydrochloride, Paracetamol and Chlorpheniramine Maleate in a Pharmaceutical Preparation Using Response Surface Methodology
(2010)A fast, accurate, precise and sensitive capillary electrophoresis method for the simultaneous determination of dextromethorphan hydrobromide, phenylephrine hydrochloride, paracetamol and chlorpheniramine maleate has been ... -
New Antioksidant Durg Development Studies on Neurohormone Melotonin and Synthetic Analogues
(2014)Antioxidants scavenge and prevent the formation of free radicals so they are exceedingly important for the treatment and management of these kinds of diseases. Therefore, in recent years, there has been an increasing ... -
Novel indole-based analogs of melatonin: synthesis and in vitro antioxidant activity studies
(2010)The aim of this study was to synthesize and examine possible in vitro antioxidant effects of indole-based melatonin analogue compounds. As a part of our ongoing study nineteen indole hydrazide/hydrazone derivatives were ... -
Novel indole-based melatonin analogues substituted with triazole, thiadiazole and carbothioamides: studies on their antioxidant, chemopreventive and cytotoxic activities
(2015)Melatonin (MLT) is a well-known free-radical scavenger, involving in the prevention of cellular damage that can lead to cancer, ageing and a variety of neurodegenerative diseases. Research on MLT-related compounds has been ... -
Novel inhibitors of the methicillin-resistant Staphylococcus aureus (MRSA)-pyruvate kinase
(2015)Novel bisindolyl-cycloalkane indoles resulted from the reaction of aliphatic dialdehydes and indole. As bisindolyl-natural alkaloid compounds have recently been reported as inhibitors of the methicillin-resistant Staphylococcus ... -
Novel N-acyl dehydroalanine derivatives as antioxidants: Studies on rat liver lipid peroxidation levels and DPPH free radical scavenging activity
(2006)Oxidative stress has been implicated in the development of many neurodegenerative diseases such as Parkinson and Alzhemier's disease and is also responsible for aging, artherosclerosis, rheumatoid arthritis and carcinogenesis. ... -
Pharmacological Applications of Nrf2 Inhibitors as Potential Antineoplastic Drugs
(2019)Oxidative stress (OS) is associated with many diseases ranging from cancer to neurodegenerative disorders. Nuclear factor-erythroid 2 p45-related factor 2 (Nrf2) is one of the most effective cytoprotective controller against ... -
Phytochemical Analysis of Podospermum and Scorzonera n-Hexane Extracts and the HPLC Quantitation of Triterpenes
(2018)Previously tested n-hexane extracts of the Scorzonera latifolia showed promising bioactivity in vivo. Because triterpenes could account for this activity, n-hexane extracts were analyzed by HPLC to identify and quantify ... -
Phytochemical analysis of podospermum and scorzonera n-hexane extracts and the hplc quantitation of triterpenes
(2018)Previously tested n-hexane extracts of the Scorzonera latifolia showed promising bioactivity in vivo. Because triterpenes could account for this activity, n-hexane extracts were analyzed by HPLC to identify and quantify ... -
Rat lung aldose reductase inhibition capacity of substituted indole hydrazide/hydrazone derivatives
(2012)Diabetes Mellitus is one of the most serious health problem facing both developed and developing countries. Long term complications lead to morbidity and mortality in patients with diabetes. Increased polyol pathway has ... -
Relatıonshıp between aldose reductase and superoxıde dısmutase ınhıbıtıon capacıtıes of ındole-based analogs of melatonın derıvatıves
(2009)Aldose reductase (AR) has been implicated in the etiology of diabetic complications. Under diabetic conditions, the elevated vascular glucose level causes an increased flux through the polyol pathway, which induces functional ... -
Screening and evaluation of antioxidant activity of some pyridazine derivatives
(2008)Antioxidants are compounds that can delay, inhibit, or prevent the oxidation of materials that can be oxidized by scavenging free radicals and help in diminishing oxidative stress. They belong to different chemical classes. ... -
Screening and evaluation of rat kidney aldose reductase inhibitory activity of some pyridazine derivatives
(2007)Aldose reductase (AR) is an enzyme that catalyzes the conversion of glucose to sorbitol, which is in turn converted to fructose by sorbitol dehydrogenase. The increased glucose flux through this metabolic pathway has been ... -
Sorbicillinoid-Based Metabolites from a Sponge-Derived Fungus Trichoderma saturnisporum
(2018)Antibacterial activity assessment and high performance liquid chromatography associated with nuclear magnetic resonance (HPLC/NMR) data revealed that the EtOAc extract of the fermented endophytic fungus Trichoderma ... -
Stochastic semi-classical description of fusion at near-barrier energies
(2010)Fusion reactions of heavy ions are investigated by employing a simple stochastic semi-classical model, which includes coupling between the relative motion and low frequency collective surface modes of colliding ions similarly ... -
Synthesis and antioxidant activity evaluations of melatonin-based analogue indole-hydrazide/hydrazone derivatives
(2012)Melatonin (MLT) is a hormone synthesized from the pineal gland. It is a direct scavenger of free radicals, which is related to its capability to defend cells from oxidative stress. Recently MLT-related compounds are under ... -
Synthesis and evaluation of antioxidant activity of new quinoline-2-carbaldehyde hydrazone derivatives: bioisosteric melatonin analogues
(2015)Overproduction of reactive oxygen species results in oxidative stress that can cause fatal damage to vital cell structures. It is known that the use of antioxidants could be beneficial in the prevention or delay of numerous ...