Browsing Makale by Department "Eczacılık Fakültesi"
Now showing items 21-40 of 71
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Crystal structure of the dipeptide cyclo(glycyl-L-glutamine)
(2002)The problem of minimal coupling of relativistic composite systems having internal degrees of freedom is investigated. The ambiguity in the introduction of various internal coordinates with the same mass spectrum can be ... -
Decreased Spexin Levels in Patients with Type 1 and Type 2 Diabetes
(2018)Background/aims: Spexin is a novel peptide which has a potential role as a biomarker of insulin resistance, diabetes, and obesity. Our aim was to measure spexin levels in lean type 1 diabetic patients and its relevance to ... -
Decreased Spexin Levels in Patients with Type 1 and Type 2 Diabetes
(2019)Background/Aims: Spexin is a novel peptide which has a potential role as a biomarker of insulin resistance, diabetes, and obesity. Our aim was to measure spexin levels in lean type 1 diabetic patients and its relevance to ... -
Decreased Spexin Levels in Patients with Type 1 and Type 2 Diabetes
(2018)Background/Aims: Spexin is a novel peptide which has a potential role as a biomarker of insulin resistance, diabetes, and obesity. Our aim was to measure spexin levels in lean type 1 diabetic patients and its relevance to ... -
Detection of reactive oxygen and nitrogen species by electron paramagnetic resonance (EPR) technique
(2017)During the last decade there has been growing interest in physical-chemical oxidation processes and the behavior of free radicals in living systems. Radicals are known as intermediate species in a variety of biochemical ... -
Detection of Reactive Oxygen and Nitrogen Species by Electron Paramagnetic Resonance (EPR) Technique
(2017)During the last decade there has been growing interest in physical-chemical oxidation processes and the behavior of free radicals in living systems. Radicals are known as intermediate species in a variety of biochemical ... -
Determination and investigation of electrochemical behaviour of 2-phenylindole derivatives: discussion on possible mechanistic pathways
(2006)Some 2-phenyl indole (2PI) derivatives were investigated electroanalytically by voltammetric determination. The electrochemical behaviour of the 2PI derivatives were studied as a function of pH at a glassy carbon and hanging ... -
Evaluation of anti-HIV activity of 5- ( 2-phenyl-3 ‘-indolal) -2- thiohydantoin
(1998)The anti-HIV activity of the previously synthesized S-( 2-phenyl-3’-indolal)-Zthiohydantoin I was evaluated. The compound, containing two structural moieties found in highly active anti-HIV agents, exhibited poor activity ... -
Evaluation of rat kidney aldose reductase inhibitory activity of some N-acetyl dehydroalanine derivatives
(2011)Aldose reductase (AR) is an enzyme that catalyzes the conversion of glucose to sorbitol, which is in turn converted to fructose by sorbitol dehydrogenase. Increased AR activity has been implicated in the pathogenesis of ... -
Evaluation of relaxant responses properties of cinnamon essential oil and its major component, cinnamaldehyde on human and rat corpus cavernosum
(2019)Cinnamomum cassia (Cinnamon) is a well-known traditional medicine with therapeutic benefits for centuries. We evaluated the effects of cinnamon essential oil (CEO) and its main component cinnamaldehyde (CA) on human corpus ... -
Food additive sodium benzoate (NaB) activates NFκB and induces apoptosis in HCT116 cells
(2018)NaB, the metabolite of cinnamon and sodium salt of benzoic acid is a commonly used food and beverage preservative. Various studies have investigated NaB for its effects on different cellular models. However, the effects ... -
In vivo activity assessment of some Tanacetum species used as traditional wound healer along with identification of the phytochemical profile by a new validated HPLC method
(2018)Objective(s): Tanacetum species are traditionally used as insecticide, and externally wound healer as well as for anti-inflammatory and antihistaminic properties. The in vivo wound-healing and anti-inflammatory potential ... -
In vivo metabolism of2-[1'-phenyl-3'-(3chlorophenyl)-2'-propenylyden]hydrazino-3-methyl4(3H)-quinazolinone in rats
(2005)The aim of this study was to investigate by HPLC the in vivo metabolism of 2-[1'-phenyl-3'-(3-chlorophenyl)-2'propenylyden]hydrazino-3-methyl-4(3H)-quinazolinone as a substrate, and as a model compound in rats. The substrate ... -
Investigation of antimicrobial activities of indole-3-aldehyde hydrazide/hydrazone derivatives
(2008)Background: Indoles and hydrazone-type compounds constitute an important class of compounds for new drug development in order to discover an effective compound against multi-drug-resistant microbial infections. Methods: A ... -
Investigation of the in vitro antioxidant behaviour of some 2-phenylindole derivatives: Discussion on possible antioxidant mechanisms and comparison with melatonin
(2006)Oxidative stress has been implicated in the development of many neurodegenerative diseases and also responsible from aging and some cancer types. Indolic compounds are a broad family of substances present in microorganisms, ... -
Investigation of the synthesis of some dehydroalanine derivatives
(2000)Dehydroamino acids represent an important class of compound as they are key intermediates in unusual amino acid and in the design of peptides and are constituents of a variety of naturally occurring antibiotic and phytotoxic ... -
İndol Türevi Yeni Bir Bileşik İle Sıçanlarda Radyasyon Nefropatisinin Engellenmesi
(2004)Bu çalışmada yeni sentezlenmiş bir indol türevi bileşiğin radyasyona sekonder gelişen nefropatiyi engelleyici etkisi olup olmadığı araştırıldı. Bu amaçla yirmi sekiz erkek Wistar sıçan dört gruba ayrıldı: Yalnız radyoterapi, ...