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dc.contributor.authorOrazakunov, Erkin
dc.contributor.authorSavaş, Berna
dc.contributor.authorKuzu, Mehmet Ayhan
dc.contributor.authorMelli, Mehmet
dc.date.accessioned2020-02-14T09:12:47Z
dc.date.available2020-02-14T09:12:47Z
dc.date.issued2008
dc.identifier.urihttps://doi.org/10.3748/wjg.14.463tr_TR
dc.identifier.urihttps://dspace.ankara.edu.tr/xmlui/handle/123456789/69513
dc.description.abstractAim: To investigate whether oral glutamine pretreatment prevents impairment of intestinal mucosal integrity during ischemia-reperfusion (I/R) in rats. Methods: The study was performed as two series with 40 rats in each. Each series of animals was divided into four groups. The first group was used as a control. Animals in the second group were only pretreated with oral glutamine, 1 g/kg for 4 d. The third group received a normal diet, and underwent intestinal I/R, while the fourth group was pretreated with oral glutamine in the same way, and underwent intestinal I/R. Intestinal mucosal permeability to 51Cr-labeled EDTA was measured in urine in the first series of animals. In the second series, histopathological changes in intestinal tissue and plasma endotoxin levels were evaluated. Results: Intestinal I/R produced a significant increase in intestinal permeability, plasma endotoxin level and worsened histopathological alterations. After intestinal I/R, permeability was significantly lower in glutamine-treated rats compared to those which received a normal diet. However, no significant change was observed in plasma endotoxin levels or histopathological findings. Conclusion: Although glutamine pretreatment seems to be protective of intestinal integrity, upon I/R injury, such an effect was not observable in the histopathological changes or plasma endotoxin level. © 2008 WJG. All rights reserved.tr_TR
dc.language.isoentr_TR
dc.relation.isversionof10.3748/wjg.14.463tr_TR
dc.rightsCC0 1.0 Universal*
dc.rights.urihttp://creativecommons.org/publicdomain/zero/1.0/*
dc.subjectAnimal modeltr_TR
dc.subjectAnimal experimenttr_TR
dc.titleEnteral glutamine pretreatment does not decrease plasma endotoxin level induced by ischemia-reperfusion injury in ratstr_TR
dc.typeArticletr_TR
dc.relation.journalWorld Journal of Gastroenterologytr_TR
dc.contributor.departmentFen Fakültesitr_TR
dc.contributor.authorID23767529700tr_TR
dc.contributor.authorID8559595900tr_TR
dc.contributor.authorID7003290371tr_TR
dc.contributor.authorID7006476267tr_TR
dc.identifier.volume14tr_TR
dc.identifier.issue3tr_TR
dc.identifier.startpage463tr_TR
dc.identifier.endpage468tr_TR
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıtr_TR
dc.identifier.issn/e-issn1007-9327


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Except where otherwise noted, this item's license is described as CC0 1.0 Universal