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Toplam kayıt 43, listelenen: 1-20
İndol Türevi Yeni Bir Bileşik İle Sıçanlarda Radyasyon Nefropatisinin Engellenmesi
(2004)
Bu çalışmada yeni sentezlenmiş bir indol türevi bileşiğin radyasyona sekonder gelişen nefropatiyi engelleyici etkisi olup olmadığı araştırıldı. Bu amaçla yirmi sekiz erkek Wistar sıçan dört gruba ayrıldı: Yalnız radyoterapi, ...
New Antioksidant Durg Development Studies on Neurohormone Melotonin and Synthetic Analogues
(2014)
Antioxidants scavenge and prevent the formation of free radicals so they are exceedingly important for the treatment and management of these kinds of diseases. Therefore, in recent years, there has been an increasing ...
Novel indole-based melatonin analogues substituted with triazole, thiadiazole and carbothioamides: studies on their antioxidant, chemopreventive and cytotoxic activities
(2015)
Melatonin (MLT) is a well-known free-radical scavenger, involving in the prevention of cellular damage that can lead to cancer, ageing and a variety of neurodegenerative diseases. Research on MLT-related compounds has been ...
Antimicrobial Activities of New Indole Derivatives Containing 1,2,4-Triazole, 1,3,4-Thiadiazole and Carbothioamide
(2018)
Objectives: In new antimicrobial drug development studies, indole and its derivatives create an important class of compounds. In addition, azoles and their derivatives were recognized to be associated with a variety of ...
Synthesis and evaluation of antioxidant activity of new quinoline-2-carbaldehyde hydrazone derivatives: bioisosteric melatonin analogues
(2015)
Overproduction of reactive oxygen species results in oxidative stress that can cause fatal damage to vital cell structures. It is known that the use of antioxidants could be beneficial in the prevention or delay of numerous ...
Synthesis and evaluation of in vitro antioxidant capacities of some benzimidazole derivatives
(2006)
New, except 1d, melatonin analogue benzimidazole derivatives were synthesized and characterized in the present study. The potential role of melatonin as an antioxidant by scavenging and detoxifying ROS raised the possibility ...
Novel inhibitors of the methicillin-resistant Staphylococcus aureus (MRSA)-pyruvate kinase
(2015)
Novel bisindolyl-cycloalkane indoles resulted from the reaction of aliphatic dialdehydes and indole. As bisindolyl-natural alkaloid compounds have recently been reported as inhibitors of the methicillin-resistant Staphylococcus ...
Behaviour of 9-Ethyl-9H-carbazole Hydrazone Derivatives Against Oxidant Systems: Protective Effect on Amyloid β-Induced Damage
(2019)
Antioxidants are helpful in prevention of several diseases related with oxidative stress including neurodegenerative disorders. In recent studies, carbazoles were given proof of promising antioxidant activities. In this ...
The Interaction of Flavonols with Membrane Components: Potential Effect on Antioxidant Activity
(2020)
Flavonols are the most widely distributed class of dietary flavonoids with a wide range of pharmacological properties due to their potent lipid peroxidation inhibition activity. The permeability and orientation of these ...
Antibacterial Evaluation of Novel Substituted Cycloheptaindoles in Staphylococcus and Enterococcus Strains
(2019)
Due to emerging resistances against antibiotics there is a strong need to find novel antibacterial agents with a novel structure to prevent early resistance developments.
Antioxidant Properties of Melatonin and its Potential Action in Diseases
(2015)
In recent years, relationship between free radicals and oxidative stress with aging, cancer, atherosclerosis, neurodegenerative disorders, diabetes, and inflammatory diseases became increasingly clear. Confirming the role ...
Detection of reactive oxygen and nitrogen species by electron paramagnetic resonance (EPR) technique
(2017)
During the last decade there has been growing interest in physical-chemical oxidation processes and the behavior of free radicals in living systems. Radicals are known as intermediate species in a variety of biochemical ...
Melatonin analogue new indole hydrazide/hydrazone derivatives with antioxidant behavior: Synthesis and structureactivity relationships
(2009)
Melatonin (MLT) is a hormone produced in the brain by the pineal gland, from the amino acid tryptophan. It is also an antioxidant hormone with a particular role in the protection of nuclear and mitochondrial DNA. In recent ...
Detection of Reactive Oxygen and Nitrogen Species by Electron Paramagnetic Resonance (EPR) Technique
(2017)
During the last decade there has been growing interest in physical-chemical oxidation processes and the behavior of free radicals in living systems. Radicals are known as intermediate species in a variety of biochemical ...
Determination and investigation of electrochemical behaviour of 2-phenylindole derivatives: discussion on possible mechanistic pathways
(2006)
Some 2-phenyl indole (2PI) derivatives were investigated electroanalytically by voltammetric determination. The electrochemical behaviour of the 2PI derivatives were studied as a function of pH at a glassy carbon and hanging ...
Electrochemical behaviorof biologically ımportantIndole derivatives
(2011)
Voltammetric techniques are most suitable to investigate the redox properties of a new drug. Use of electrochemistry is an important approach in drug discovery and research as well as quality control, drug stability, and ...