Search
Now showing items 21-30 of 43
Novel indole-based analogs of melatonin: Synthesis and in vitro antioxidant activity studies
(2010)
The aim of this study was to synthesize and examine possible in vitro antioxidant effects of indole-based melatonin analogue compounds. As a part of our ongoing study nineteen indole hydrazide/hydrazone derivatives were ...
In vivo metabolism of2-[1'-phenyl-3'-(3chlorophenyl)-2'-propenylyden]hydrazino-3-methyl4(3H)-quinazolinone in rats
(2005)
The aim of this study was to investigate by HPLC the in vivo metabolism of 2-[1'-phenyl-3'-(3-chlorophenyl)-2'propenylyden]hydrazino-3-methyl-4(3H)-quinazolinone as a substrate, and as a model compound in rats. The substrate ...
Novel indole-based analogs of melatonin: synthesis and in vitro antioxidant activity studies
(2010)
The aim of this study was to synthesize and examine possible in vitro antioxidant effects of indole-based melatonin analogue compounds. As a part of our ongoing study nineteen indole hydrazide/hydrazone derivatives were ...
Synthesis and structure of 2-[(5,6,7,8-tetrahydro-5,5,8,8tetramethyl-2-naphthalene)]-5-benzimidazole ethylcarboxylate monohydrat
(2000)
Aspartofaprograminvestigatingtheconformationsofpotentialanticarcinogensandantioxidants, the structure of the title compound C24H28N2O2 H2O is reported. The monohydrate crystallizes in the monoclinic space group P2/c with ...
Preliminary evaluation of rat kidney aldose reductase inhibitory activity of 2-phenylindole derivatives: Affiliation to antioxidant activity
(2007)
Diabetic complications including nephropathy, neuropathy, and cataract are leading causes of end-stage renal diseases and neurological disorders. Aldose reductase (AR), the rate-limiting enzyme of the polyol pathway, ...
Rat lung aldose reductase inhibition capacity of substituted indole hydrazide/hydrazone derivatives
(2012)
Diabetes Mellitus is one of the most serious health problem facing both developed and developing countries. Long term complications lead to morbidity and mortality in patients with diabetes. Increased polyol pathway has ...
Comparative effect of N-substituted dehydroamino acids and α-tocopherol on rat liver lipid peroxidation activitie
(Journal of Enzyme Inhibition and Medicinal Chemistry, 2009)
Free radical damage has been associated with a growing number of diseases and conditions, such as autoimmune diseases, neurodegenerative disorders and multiple types of cancer. Some dehydroamino acids and corresponding ...
Relatıonshıp between aldose reductase and superoxıde dısmutase ınhıbıtıon capacıtıes of ındole-based analogs of melatonın derıvatıves
(2009)
Aldose reductase (AR) has been implicated in the etiology of diabetic complications. Under diabetic conditions, the elevated vascular glucose level causes an increased flux through the polyol pathway, which induces functional ...
