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Preliminary evaluation of rat kidney aldose reductase inhibitory activity of 2-phenylindole derivatives: Affiliation to antioxidant activity
Diabetic complications including nephropathy, neuropathy, and cataract are leading causes of end-stage renal diseases and neurological disorders. Aldose reductase (AR), the rate-limiting enzyme of the polyol pathway, ...
Rat lung aldose reductase inhibition capacity of substituted indole hydrazide/hydrazone derivatives
Diabetes Mellitus is one of the most serious health problem facing both developed and developing countries. Long term complications lead to morbidity and mortality in patients with diabetes. Increased polyol pathway has ...
Relatıonshıp between aldose reductase and superoxıde dısmutase ınhıbıtıon capacıtıes of ındole-based analogs of melatonın derıvatıves
Aldose reductase (AR) has been implicated in the etiology of diabetic complications. Under diabetic conditions, the elevated vascular glucose level causes an increased flux through the polyol pathway, which induces functional ...
Evaluation of rat kidney aldose reductase inhibitory activity of some N-acetyl dehydroalanine derivatives
Aldose reductase (AR) is an enzyme that catalyzes the conversion of glucose to sorbitol, which is in turn converted to fructose by sorbitol dehydrogenase. Increased AR activity has been implicated in the pathogenesis of ...
Screening and evaluation of rat kidney aldose reductase inhibitory activity of some pyridazine derivatives
Aldose reductase (AR) is an enzyme that catalyzes the conversion of glucose to sorbitol, which is in turn converted to fructose by sorbitol dehydrogenase. The increased glucose flux through this metabolic pathway has been ...