Aşit, MertSaka, Mendane2024-05-102024-05-102023https://dspace.ankara.edu.tr/handle/20.500.12575/90815Cancer is the second leading cause of death worldwide, and although the prognosis for patients has improved, it is still poor in a significant proportion of cases. Complex and inconclusive approaches to anticancer treatment in the human body motivate the search for new ways to create an anticancer environment. Studies have shown that probiotics, prebiotics, synbiotics and postbiotics are effective in their use as adjunctive therapy in cancer treatment. Postbiotics, from the biotic family, are health-promoting microbial metabolites offered as a functional food or dietary supplement. They directly affect the body's signaling pathways or indirectly manipulate the metabolism and composition of the intestinal microflora. The administration of postbiotics is an effective complementary strategy to fight cancer. In this review, studies including the antitumoral effects of postbiotics and their role in metastatic cancers were examined and the main findings showing the usefulness of postbiotic sources in tumor cells were summarized. Postbiotics can be considered as adjunctive therapy in cancer treatment and may help reduce the side effects caused by treatment methods. In addition, more in vivo and in vitro studies are needed to evaluate the effects of postbiotics on cancer in detail.enAntitumor agentscancermetastasisArticle