Mohanappriya, G.Vijayalakshmi, D.2021-11-042021-11-042019-08-01https://doi.org/10.31801/cfsuasmas.526546http://hdl.handle.net/20.500.12575/75884Topological invariants are the graph theoretical tools to the theoretical chemists, that correlates the molecular structure with several chemical reactivity, physical properties or biological activity numerically. A function having a set of networks(graph, molecular structure) as its domain and a set of real numbers as its range is referred as a topological invariant(index). Topological invariants are numerical quantity of a network that are invariant under graph isomorphism. Topological invariants such as Zagreb index, Randić index and multiplicative Zagreb indices are used to predict the bioactiviy of chemical compounds in QSAR/QSPR study. In this paper, we compute the general expression of certain degree based topological invariants such as second Zagreb index, F-index, Hyper-Zagreb index, Symmetric division degree index, irregularity of Splitting graph. And also we obtain upper bound for first and second multiplicative Zagreb indices of Splitting graph of a graph H, (S′(H)).enTopological invariantDegree based invariantSplitting graphArticle682134113492618-6470