Süzen, SibelSeçkin, ÖzdenShirinzadeh, Hanif2019-06-272019-06-27201010.3390/molecules15042187http://hdl.handle.net/20.500.12575/66846https://doi.org/10.3390/molecules15042187The aim of this study was to synthesize and examine possible in vitro antioxidant effects of indole-based melatonin analogue compounds. As a part of our ongoing study nineteen indole hydrazide/hydrazone derivatives were synthesized, characterized and their in vitro antioxidant activity was investigated by three different assays: by evaluating their reducing effect against oxidation of a redox sensitive fluorescent probe, by examining their protective effect against H(2)O(2)-induced membrane lipid peroxidation and by determining their inhibitory effect on AAPH-induced hemolysis of human erythrocytes. The results indicated significant strong antioxidant activity for most of the compounds, when compared to melatonin.ScopusenIndoleHydrazoneHydrazideMelatoninSynthesisAntioxidant activityArticle150421872202