Varynskyi, Borys2020-04-012020-04-012019https://doi.org/10.33483/jfpau.480073http://hdl.handle.net/20.500.12575/70848Objective: Aim of the research to make forced degradation study of piperidinium 2-((5-(furan-2-yl)-4- phenyl-4H-1,2,4-triazol)-3-yl) acetate in active pharmaceutical ingredient (API), 0.1% solution and 1% solution for injection. Influence of the sodium hydroxide, hydrochloride acid, 3% Н2О2, temperature, UV radiation on piperidinium 2-((5-(furan-2-yl)-4-phenyl-4H-1,2,4-triazol)-3-yl) acetate substance, 0.1% solution and 1% solution for injections was studied. Material and Method: Agilent 1260 Infinity HPLC System. Agilent single-quadrupole mass spectrometer 6120. Result and Discussion: Dependence of the quantitative content of the piperidinium 2-((5-(furan-2-yl)-4- phenyl-4H-1,2,4-triazol)-3-yl) acetate from exposition time was determined. The composition of degradation products formed under the action of an oxidizer (3%Н2О2) was established. The composition of degradation products which were formed under the influence of UV radiation was proposed.enESI mass spectrometryForced degradation studyArticle43021171341015-3918