Atabekoğlu, CemAbilova, Vüsale2022-06-012022-06-012014http://hdl.handle.net/20.500.12575/80808Gonadotropins, depending on their source, are obtained from human (h) and widely used for auxiliary reproduction techniques by classified as recombinant, and they are important preparate group for ovulation induction. Usually, gonadotropin preparates are important in terms of effectiveness, reliability, and cost. Gonadotropins influence oocytes number and determine pregnancy rates. However, producing too many oocytes increases the risk of ovarian hyper-stimulation syndrome. Previous studies show that clinically recFSH preponderate over pure uFSH, but yet most of recent studies proofs that both medicine group have the same effect. In previous works generally recFSH and pure uFSH are compared in IUI cycles and agonist protocol. Objective: The aim of this study is to compare follicular development, number of obtained oocytes, metaphase 1, metaphase 2, germinal vesicle rates, the number of 14-mm and 17-mm follicle on HCG day, endometrial double-wall thickness on transfer day, the number of embryos transferred, quality of clinical pregnancy, abortion, live birth rates and cost-effectiveness for pure-urinary-follicle-stimulating- hormone (pure uFSH) in which GnRH antagonist used in intra-cytoplasmic-sperm- injection (ICSI) cyclus and recombinant-follicle-stimulating-hormone (rFSH) applied patients. Materials and methods: A total of 60 infertile patients were randomized into two groups. In Group 1, antagonist protocol is applied to 40 patients, and Gonal-F and Puregon are used as recombinant FSH. In Group 2, as highly purified urinaryFSH, Fostimon is applied to 20 patients who is under antagonist protocol. Later groups are compared in terms of clinical parameters, follicle growth parameters, embryo transfer parameters and cost. Results: There is no significant difference between two groups, for follicles number with 14 mm and more on HCG day, estradiol levels, germinal vesicle numbers, number of embryos transferred per patient, B quality embryos number and transfer day endometrial double wall. From the point of 17mm and more follicle development on HCG day, it is observed that, Group 1 had statistically significant more effect on follicular development compared to Group 2 (p<0,05). From the point of influencing the number of obtained oocytes, it is observed that Group 1 has significantly more oocytes compared to Group 2 (p<0,01). The number of oocytes in Metaphase 1 is remarkable (p=0.003) for Group 1, though the number of oocytes in Metaphase 2 is more remarkable (p =0.020). In addition, it is observed the results of the number of A quality embryos (p = 0.05), the number of frozen embryos (p = 0.002) and the number of patients with frozen embryos (p = 0.003) is significant in favor of recFSH (p=0.05). In our study, transfer cancellation rate in üFSH group (p=0.04) is found significant. For each group, percentages of clinical pregnancy (respectively 62.5% and 25%), abortion (respectively 10% and 15%), live births (respectively 52.5% and 10%) were given. Cost analysis between groups show that average cost of treatment and cost per cyclus are not significant, and the cost per pregnancy is found high with 16% in üFSH group. Conclusion: Pure üFSH preparates has less clinical effectiveness and more cost per pregnancy on oocyte and embryo parameters compared to recFSH preparates.truriner FSHrekombinant FSHantagonist protokolMedicalThesis