Dirican, BaharGörür, Salih2022-08-102022-08-102012http://hdl.handle.net/20.500.12575/83037In this thesis, treatment plans of 9 patients with Glioblastoma Multiforme (GBM) diagnosis were done with Three Dimensional Conformal Radiotherapy (3DCRT) and Intensity Modulated Radiotherapy (IMRT) techniques using cross-sectional images of pre-treatment Computed Tomography (CT) and the data obtained were compared.4-field box technique (0 °, 90 °, 180 °, 270 °) or 4 different field gantry angles in 3DCRT technique and "inverse", "step and shoot" technique, 5 fields, 3 segments in IMRT technique were used. Dose constraints is determined as of 60 Gy for brain stem, 56 Gy for optic chiasm , 55 Gy for the optic nerves, 35 Gy for the eyes, 7 Gy for lenses. The prescribed dose was total dose of 60 Gy to planning target volume for both treatment techniques using 2 Gy per daily fraction.When compared with the 3DCRT, in IMRT plans, maximum dose value of target volume was decreased by 0,9%, mean dose value of target volume was increased by 0,1%. IMRT plans provided 1% more homogeneous dose distribution and critical organ doses decreased 5,6% for brain stem, 10,7% for optic chiasm, 26,8% for right optic nerve, 26,6% for left optic nerve, 32,6% for right eye, 39,8% for left eye, 7,8% for right lens, 33,8% for left lens, compared with 3DCRT plans.It was concluded that, in treatment of GBM tumors, IMRT technique is more appropriate than 3BCRT, with minimum critical organ doses.trGlioblastoma multiformebeyin tümörümasterThesis