Kumbasar, HakanKapucu, Bilge Bilgin2022-06-132022-06-132015http://hdl.handle.net/20.500.12575/81721The Effect of Pre-transplantation Psychological Well-being on Hematological Reconstitution Following Autologous Peripheral Stem Cell Transplantation in Multipl Myeloma Patients Objective: The aim of this study was to identify the effect of pre-transplantational depression and anxiety on neutrophil and thrombocyte engraftments which are the signs of hematological reconstitution in multipl myeloma patients who are undergoing autologous peripheral stem cell transplantation. Method: 46 patients with Multipl Myeloma who were hospitalized in Ankara University School of Medicine, Hematology Department for autologous periferal stem cell transplantation were included in the study. Patients completed the Hospital Anxiety and Depression Scale between the days 0 and 7 before the transplantation. The engraftment days were determined by the post-transplantational daily routine complete blood count. The data was evaluated by using Mann WhitneyU test. Results:The neutrophil engraftment was significantly delayed in depressed patients when compared to non-depressed ones (p=0.036). Factors other than depression that may affect the engraftment days were assessed for a possible difference between the depressed and non-depressed groups and no difference was found between the groups. Also, there was no significant difference between depressed and non-depressed patients when analyzed for thrombocyte engraftment (p=0.770). Conclusion: The results show that neutrophil engraftment was delayed in patients with depression. This suggests that depression may adversly affect the recovery after stem cell transplantation. Larger sample studies are necessary.trdepresyontransplantasyonnötrofilMedicalThesis