Relatıonshıp between aldose reductase and superoxıde dısmutase ınhıbıtıon capacıtıes of ındole-based analogs of melatonın derıvatıves

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dc.contributor.authorSüzen, Sibel
dc.contributor.departmentEczacılık Fakültesitr_TR
dc.contributor.otherDaş Evci̇Men, Net
dc.date.accessioned2020-03-18T07:20:17Z
dc.date.available2020-03-18T07:20:17Z
dc.date.issued2009
dc.description.abstractAldose reductase (AR) has been implicated in the etiology of diabetic complications. Under diabetic conditions, the elevated vascular glucose level causes an increased flux through the polyol pathway, which induces functional and morphological changes associated with secondary diabetic complications such as cataract, neuropathy, and nephropathy. Oxidative stress, antioxidants, and the polyol pathway have recently been found to be linked in pathological states. A large number of structurally different compounds have been studied as potent in vitro AR inhibitors (ARIs). However, with few exceptions, these compounds did not show clinical benefit, and some even produced serious side effects. In view of the ARI activity of certain indole derivative compounds and antioxidant properties of melatonin, we investigated some indole-based analogs of melatonin derivatives. Antioxidant and ARI activity tests were applied to nine indole derivatives that are substituted at the third and fifth positions. Also, the relationship between ARI and antioxidant enzyme activity is discussed.tr_TR
dc.description.indexwos
dc.description.indexScopus
dc.identifier.endpage681tr_TR
dc.identifier.issue4tr_TR
dc.identifier.startpage675tr_TR
dc.identifier.urihttps://doi.org/10.2298/ABS0904675Dtr_TR
dc.identifier.urihttp://hdl.handle.net/20.500.12575/70718
dc.identifier.volume61tr_TR
dc.language.isoentr_TR
dc.relation.isversionof10.2298/ABS0904675Dtr_TR
dc.relation.journalArchives of Biological Sciencestr_TR
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıtr_TR
dc.subjectAldose reductasetr_TR
dc.subjectAntioxidanttr_TR
dc.subjectDiabetes mellitustr_TR
dc.subjectİndoletr_TR
dc.subjectMelatonintr_TR
dc.titleRelatıonshıp between aldose reductase and superoxıde dısmutase ınhıbıtıon capacıtıes of ındole-based analogs of melatonın derıvatıvestr_TR
dc.typeArticletr_TR

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