Browsing by Author "Asmafiliz, Nuran Gürün"

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    Mono ve bis(ferrosenil)-fosfazen türevlerinin sentezi, kristal yapıları, spektroskopik ve stereojenik özelliklerinin incelenmesi ve biyolojik aktifliklerinin araştırılması
    (Fen Bilimleri Enstitüsü, 2011) Asmafiliz, Nuran Gürün; Kılıç, Zeynel; Kimya
    In this study, five different bidentate ferrocenyldiamines (1-5) have been prepared as starting compounds. The reactions of mono and bisferrocenyldiamines with hexachlorocyclotriphosphazene (trimer), N3P3Cl6, lead to the formation of tetrachloro mono and bisferrocenylphophazenes (6-10) and the reactions of these compounds with pyrrolidine afford tetrakispyrrolidino phosphazene derivatives (11-15) in THF. Afterwards, the ferrocenylphosphazenes with the stereogenic properties (16-23) have been prepared by the reactions of 6, 7, 9 and 10 with sodium(3-amino-1-propanoxide) in THF and the chiral properties are determined using the 31P-NMR data obtained in the presence of chiral solvating agent, [(S)-(+)-2,2,2-trifluoro-1-(9?-anthryl)ethanol] (CSA). On the other hand, the partly or fully crown-ether-substituted ferrocenylphosphazenes (24-28), the possible ligating agents for alkali and alkaline-earth metal cations, are obtained from the reactions of 6 and 7 with 1-aza-12-crown-4 and 1-aza-15-crown-5 in o-xylene. The structural investigations of the compounds have been verified by elemental analyses, mass spectrometry (ESI-MS), Fourier transform IR, 1H, 13C, and 31P NMR, and DEPT, COSY, HETCOR, and HMBC techniques. In addition, the solid-state structures of some mono and bisferrocenylphosphazenes (6, 7, 9, 10, 11, and 15) are also determined by X-ray crystallography, and the molecular structures, hydrogen bondings and their ring conformations have also been investigated. The electrochemical behaviors of the most of the compounds have been determined by the cyclic voltammetric technique. Besides that, the antimicrobial activities against some bacteria and yeast strains, the antituberculosis activities against reference strain Mycobacterium Tuberculosis H37Rv, and the interactions of plasmid DNA of the compounds are investigated.